Institute of Cell Biology National Academy of Sciences of Ukraine

Department of Regulation of Cell Proliferation and Apoptosis

Head of Department – Rostyslav Stoika, Ph.D., Dr. Sci., Professor, Corresponding Member of National Academy of Sciences of Ukraine.

The Department was established in 1993, and since that time it is headed by Rostyslav Stoika, Corresponding Member of National Academy of Sciences of Ukraine (2006). He was elected as a Foreign Member of the Polish Academy of Sciences and Arts (2002), Soros Professor (1997), and awarded by National Academy of Sciences of Ukraine with A.V. Palladin prize in Biochemistry (1986) and R.E. Kavetsky prize in Experimental Oncology (2007). State Prize in Science and Technology of Ukraine in 2020 (R. Stoika and R. Panchuk). Honored Worker of Science and Technology of Ukraine (2020). S.Z. Gzycky Prize in Biochemistry (2020).

R.S. Stoika is author and co-author of 375 articles in scientific journals, including 253 articles in journals of Scopus database. His Hirsch Index is 21 (Scopus), the total impact factor is 277 (Scopus), the total number of citations is over 1800 (Scopus). He is the co-author of 4 monographs, co-author of Chapters in 17 monographs, including in 9 monographs of the international publishers. He is an author of 3 methodical manuals, 19 patents of Ukraine, including 10 patents for inventions, co-author of 2 patent applications for the United States and the European PCT. The Editor-in-Chief of the monograph "Multifunctional nanomaterials for biology and medicine: molecular design, synthesis and application" (2017). The Editor-in-Chief of the monograph “Biomedical nanomaterials: From design and synthesis to imaging, application and environmental impact” which is in process of publication in 2021 by Springer-Nature publishing house.

Principal directions of scientific research at the Department:

1. Structure-function inter-relationships in the antioneoplastic (in vitro) and anticancer (in vivo) action of novel synthetic and natural compounds of different chemical structure.
2. Biochemical and cellular mechanisms of appearance and biological role of the biomarkers of apoptosis. The role of glycocalyx components in the intercellular interactions.
3. Novel mechanisms and potential protein and peptide triggers in pathogenesis of autoimmune diseases. Role of immunogenic cell death in cancer suppression.
4. Mechanisms of enhancement of action of medicines at their delivery to target cells by the nanoscale materials of synthetic and natural origin. Novel nanomaterials for non-viral delivery of nucleic acids to target cells of different origin (microorganisms, mammalian and plant cells).