2017

International Projects:

 

1. Project NASU and STCU «In silico modeling as a core of rational metabolic engineering of yeast Hansenula polymorpha for improvement of the high-temperature xylose alcoholic fermentation" (in collaboration with Uppsala University, Sweden).


2. Grant OPUS 11 "The role of transcription factors in regulation of glucose and xylose metabolism and alcoholic fermentation in the non-conventional yeasts Ogataea polymorpha" (in collaboration with Rzeszow University, Poland).

 

National scientific grants:

 

1. Within the framework of Scientific Program "Molecular and cellular biotechnology for medicine, industry and agriculture" 4 research projects were carried out:
   
   • "Mechanisms of degradation of peroxisomal and cytosolic proteins in methylotrophic yeasts and construction of overproducers of industrially valuable proteins on the basis of mutant strains with damage to these mechanisms".
   • "The genetic control of biosynthesis and transport of riboflavin in flavinogenic yeasts".
   • "Application of metabolic engineering for construction of Saccharomyces cerevisiae strains capable of overproduction of glycerol under anaerobic conditions".
   • "Creation of drought-resistant plant lines by overexpression of yeast genes of trehalose biosynthesis" in collaboration with the State establishment "Institute of Food Biotechnology and Genomics NAS of Ukraine".


2. According to the results of general academic competition of scientific and technical projects and the order of the Presidium of the NAS of Ukraine from 29.03.2017 №229 science and technical project was carried out: "Development of laboratory and semi-industrial regulations for obtaining baker's yeast capable of oversynthesis of trehalose and glycerol and therefore resistant to drying, freezing and osmotic shock".


3. Within the framework of a targeted complex program of scientific research NAS of Ukraine "Biological resources and new technologies of bioconversion" 3 research projects were carried out:
   
   • "Metabolic engineering of methylotrophic yeast Hansenula polymorpha to improve alcoholic fermentation of alternative carbon sources (glycerol and xylose)".
   • "Metabolic engineering of industrial strains of Saccharomyces cerevisiae – ethanol producers to increase their thermotolerance".
   • "Selection and construction of thermotolerant strains of Saccharomyces – producers of bioethanol using mutagenesis" in cooperation with the Department of Analytical Biotechnology.


4. Within the framework of a complex scientific and technical program NAS of Ukraine "Sensorsʼ devices for medical-ecological and industrial-technological requirements: meteorological support and research exploitation" in cooperation with the Department of Analytical Biotechnology research project: "The development and trial exploitation of a portative analyzer based on amperometric enzyme biosensors for quality control of beverages in winery. Development of biosensor methods of arginine analysis in wine by using arginine-hydrolyzi.

 

2018

International Projects:

 

1. Project NASU and STCU "In silico modeling as a core of rational metabolic engineering of yeast Hansenula polymorpha for improvement of the high-temperature xylose alcoholic fermentation" (in collaboration with Uppsala University, Sweden).


2. Grant OPUS 11 "The role of transcription factors in regulation of glucose and xylose metabolism and alcoholic fermentation in the non-conventional yeasts Ogataea polymorpha" (in collaboration with Rzeszow University, Poland).


3. Competition of joint Ukrainian-Lithuanian research projects “Improving the efficiency of transport of xylose thermotolerant yeast Ogataea polymorpha to improve the parameters of alcoholic fermentation" (in collaboration with Vytautas the Great University, Lithuania).

 

National scientific grants:

 

1. Scientific and technical project "Development of technology for the production of ethyl alcohol based on engineered strains of alcoholic yeast capable of overproduction of ethanol" (in cooperation with the Hungarian distillery).


2. Within the framework of Scientific Program "Molecular and cellular biotechnology for medicine, industry and agriculture" 4 research projects were carried out:
   
   • "Mechanisms of degradation of peroxisomal and cytosolic proteins in methylotrophic yeasts and construction of overproducers of industrially valuable proteins on the basis of mutant strains with damage to these mechanisms".
   • "The genetic control of biosynthesis and transport of riboflavin in flavinogenic yeasts".
   • "Application of metabolic engineering for construction of Saccharomyces cerevisiae strains capable of overproduction of glycerol under anaerobic conditions".
   • "Creation of drought-resistant plant lines by overexpression of yeast genes of trehalose biosynthesis" in collaboration with the State establishment "Institute of Food Biotechnology and Genomics NAS of Ukraine".


3. Within the framework of a targeted comprehensive research program of of the NAS of Ukraine "Biofuel resources and bioenergy" research project "Construction of thermotolerant yeast strains with improved parameters of substrate bioconversion (xylose, glucose, glycerin) to ethanol was carried out.

 

2019

International Projects:

 

1. Competition of joint Ukrainian-Austrian scientific projects "Recombinant strains of Komagataella phaffii yeast producing flavin antibiotics aminoriboflavin and roseoflavin".


2. Grant OPUS 11 "The role of transcription factors in regulation of glucose and xylose metabolism and alcoholic fermentation in the non-conventional yeasts Ogataea polymorpha" (in collaboration with Rzeszow University, Poland).


3. Competition of joint Ukrainian-Lithuanian research projects "Improving the efficiency of transport of xylose thermotolerant yeast Ogataea polymorpha to improve the parameters of alcoholic fermentation" (in collaboration with Vytautas the Great University, Lithuania).

 

National scientific grants:

 

1. Within the framework of Scientific Program "Molecular and cellular biotechnology for medicine, industry and agriculture" 4 research projects were carried out:
   
   • "Mechanisms of degradation of peroxisomal and cytosolic proteins in methylotrophic yeasts and construction of overproducers of industrially valuable proteins on the basis of mutant strains with damage to these mechanisms".
   • "The genetic control of biosynthesis and transport of riboflavin in flavinogenic yeasts".
   • "Application of metabolic engineering for construction of Saccharomyces cerevisiae strains capable of overproduction of glycerol under anaerobic conditions".
   • "Creation of drought-resistant plant lines by overexpression of yeast genes of trehalose biosynthesis" in collaboration with the State establishment "Institute of Food Biotechnology and Genomics NAS of Ukraine".


2. Project of research works of young scientists of the National Academy of Sciences of Ukraine 2019-2020 "Study of the role of peroxisomes in metabolism and alcoholic fermentation of xylose and glycerin in the yeast Ogataea polymorpha"

 

2020

International Projects:

 

1. Joint Ukrainian-Polish project "Identification of genes involved in the autophagic degradation of soluble proteins in yeast and human cells" (in collaboration with the University of Rzeszow).


2. Competition of joint Ukrainian-Austrian research projects "Recombinant strains of yeast Komagataella phaffii, producing flavin antibiotics aminoriboflavin and roseoflavin"


3. Grant "Opus" on "Transcription activators and repressors in the regulation of riboflavin synthesis by iron in the flavinogenic yeasts Candida famata" (in collaboration with the University of Rzeszow, Poland).

 

National scientific grants:

 

1. NDFU "Science for Human and Society Safety" competition "Development of a vaccine against SARS-CoV-2 based on the expression of S protein fragments in yeast and the study of the immune response in laboratory animals".


2. NDFU competition "Science for the safety of man and society" "Creation of yeast producers of new flavin antibiotics".


3. Research work of young scientists of the National Academy of Sciences of Ukraine "Study of the role of peroxisomes in the metabolism and alcoholic fermentation of xylose and glycerin in the yeast Ogataea polymorpha".


4. Support of priority for the state scientific research and scientific and technical (experimental) developments of the Department of Biochemistry, Physiology and Molecular Biology of the NAS of Ukraine "Mechanisms of regulation of alcoholic fermentation in yeast".


5. Target research program of the National Academy of Sciences of Ukraine "Genomic, molecular and cellular basis for the development of innovative biotechnologies" "Construction of ethanol producers from glycerol based on methylotrophic yeast Komagataella phaffii and Ogataea polymorpha".


6. Target research program of the National Academy of Sciences of Ukraine "Biofuel resources and bioenergy" "Development of new approaches to the construction of yeast strains Ogataea polymorpha with improved alcoholic fermentation of pentose sugars".


7. Target research program of the NAS of Ukraine "Smart" new generation sensor devices based on modern materials and technologies" "Development and optimization of enzyme electrochemical biosensors based on new functional nanomaterials for determination of arginine and their application for quality control of fruit and berry juices and products hygiene" (together with the Department of Analytical Biotechnology).