ROCP Scientific Interests » Institute of Cell Biology NAS of Ukraine
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Institute of Cell Biology National Academy of Sciences of Ukraine

 

Department of Regulation of Cell Proliferation and Apoptosis

 

The main research topics:

 

  • molecular mechanisms of regulation of proliferation and apoptosis of tumor and immune cells of mammalians;
  • search for and identification of novel bio-markers of apoptosis at antitumor chemotherapy;
  • detection, isolation and biochemical characterization of novel abzymes (catalytically active antibodies) in blood serum of patients with autoimmune diseases, cancer, and in human milk;
  • detection, isolation and characterization of novel protein and peptide triggers in pathogenesis of autoimmune and oncological diseases;

  • role of immunogenic cell death in cancer suppression;
  • search for novel natural (plants and higher mushrooms) low molecular substances (alkaloids and tri-terpens) possessing anticancer and immunomodulating activities;
  • bio-evaluation of novel nanoscale materials (mineral and polymeric) with conjugated functional bio-elements (specific lectin or immunoglobulin) and label (fluorescent dye or super-paramagnetic core) (developed in collaboration with the Department of Organic Chemistry of National University "Lviv Polytechnica" and other research partner institutions);
  • the application of nanoscale polymeric materials for drug and gene delivery;
  • isolation of chitosan and preparation of its low molecular weight derivatives; the use of these derivatives for drug and gene delivery;
  • cellular and molecular mechanisms of anticancer action of novel antibiotics of landomycin family;
  • cellular and molecular mechanisms of anticancer action of novel derivatives of berberine alkaloid (developed in collaboration with Institute of Biology, Shendong Academy of Sciences, China);
  • cellular and molecular mechanisms of anticancer action of novel 4-thiazolidinone derivatives (developed in collaboration with Danylo Halytsky Lviv National Medical University);
  • cellular and molecular mechanisms of anticancer action of novel thiazol derivatives (developed in collaboration with Ivan Franko Lviv National University).
    institut(at)cellbiol.lviv.ua