Institute of Cell Biology National Academy of Sciences of Ukraine

Department of Regulation of Cell Proliferation

The main research topics:

• molecular mechanisms of regulation of proliferation and apoptosis of the tumor and immune mammalian cells;


• role of transforming growth factor type beta in the mechanisms of tumor cell resistance to specific anticancer drugs and in the action of doxorubicine;


• search for and identification of novel plasma membrane glycoprotein markers of the programmed cell death (apoptosis);


• study of the role of novel proto-oncogene - pituitary tumor transforming gene - in the immune system;


• biochemical characteristics of abzymes (catalytically active antibodies) in patients with autoimmune diseases, cancer, and in normal human milk;


• search for novel natural low molecular substances (alkaloids and tri-terpens) possessing anticancer and immunomodulating activities;


• testing of novel nanoscale materials (mineral and polymer) with conjugated functional elements (specific lectin or immunoglobulin) and label (fluorescent dye or super-paramagnetic core) for biomedical application (ex. drug and gene delivery) - developed in collaboration with the Department of Organic Chemistry of National University «Lviv Polytechnic»);


• cellular and molecular mechanisms of anticancer action of novel antibiotics of landomycin family;


• cellular and molecular mechanisms of anticancer action of novel 4-thiazolidone derivatives - developed in collaboration with Danylo Halytsky Lviv National Medical University);


• molecular mechanisms of cancer-dependent endogenous intoxication in tumor-bearing experimental animals (mice).