1. Structure-function inter-relationships in the antioneoplastic (in vitro) and anticancer (in vivo) action of novel synthetic and natural compounds of different chemical structure.
2. Biochemical and cellular mechanisms of appearance and biological role of the biomarkers of apoptosis. The role of glycocalyx components in the intercellular interactions.
3. Novel mechanisms and potential protein and peptide triggers in pathogenesis of autoimmune diseases. Role of immunogenic cell death in cancer suppression.
4. Mechanisms of enhancement of action of medicines at their delivery to target cells by the nanoscale materials of synthetic and natural origin. Novel nanomaterials for non-viral delivery of nucleic acids to target cells of different origin (microorganisms, mammalian and plant cells).

Summarized number of papers in the peer-reviewed journals – 282 (total cited – 264), summarized Impact Factor – approx. 284, Sum of Citations (Scopus) – 2058, Hirsch Index – 21. Patents – 20.

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List of Publications

1990-1995 – Associate Professor, Department of Biochemistry, Lviv State University.

1995–current – Professor, Department of Biochemistry, Lviv National University.

1998-2000 – Professor, Dept. of Medical Biology and Genetics, Lviv State Medical University.

2015-current – Professor, Dept. of Normal Physiology, Lviv National Medical University.

Member of the Presidium of the Ukrainian Biochemical Society.

Head of Lviv Divisison of the Ukrainian Biochemical Society.

Member of Fellowship Committee of FEBS (Federation of European Biochemical Societies) (2016-2020).

President of the Ukrainian Council of Science Editors.

Member of the Presidium of Shevchenko Scientific Society.

California University Los Angeles (UCLA) – 1994.

Cedars-Sinai Medical Centre (CSMC) research institute in Los Angeles (USA) – 1999-2000.

Supervision of research grants: Native (2015-2020) – 5, international (1990-2020) – 10.

Supervison of Dissertations: Doctor of Biological Sciences – 3, Phylosophy Doctor (PhD) – 23.

2020 – Stepan Hzhycky Award in Biochemistry.

2020 – State Award of Ukraine in Science and Technology.

2020 – Distinguished Worker in Science and Technology of Ukraine.

2018 – Member of Identification Committee on Science in Ukraine.

2007 – R.E. Kavetsky Prize in Experimental Oncology, National Academy of Sciences of Ukraine.

2006 – Corresponding Member in Biochemistry, National Academy of Sciences of Ukraine.

2002 – Foreign Member of Polish Academy of Science and Arts (Academija Umetnosti).

2000 – Actual Member of Shevchenko Scientific Society.

1997 – George Soros Professor Award (in Biochemistry).

1986 – A.V. Palladin Prize and Medal in Biochemistry, Academy of Sciences of Ukraine.

1. Structural and functional relationships of anti-neoplastic (in vitro) and antitumor (in vivo) action of new synthetic and natural compounds of different chemical structure.
2. Biochemical and cellular mechanisms of appearance of biomarkers of apoptosis and their biological role. The role of glycocalyx components in intercellular interactions.
3. Chitosan and chitosan derivatives, their use in hemocoagulation, and as an antibacterial drug.

Actual Member of Shevchenko Scientific Society.

1. Applied Microbiology and Biotechnology (metabolic engineering, analytical biotechnology).
2. Biochemistry (regulatory aspects of metabolism in microorganisms).
3. Protein Biotechnology (isolation and purification of proteins, their structural and physico-chemical characterization).
4. Enzymology (fundamental and applied aspects), Biosensorics, Environmental Biotechnology, Nanobiotechnology.

Author of more than 560 scientific publications, including 215 full-length papers and 12 inventions (more than 125 – in journals with impact factor). Hirsch index (h-index) of publications – 24 (Scopus).

List of Publications

2000-present – Head of the Department of Analytical Biotechnology, Institute of Cell Biology, NAS of Ukraine;

1985-2000 – Senior Researcher, Institute of Cell Biology, NAS of Ukraine, Lviv, Ukraine;

1980-1985 – Assistant of Professor (Docent), Chair of Biochemistry, Ivan Franko State University, Lviv, Ukraine;

1978-1980 – Senior Researcher, Institute of Hematology and Blood Transfusiology, Lviv, Ukraine.

1974-1977 – Postgraduate student of Moscow University, Chemical Faculty, Department of Chemistry of Natural Compounds;

1969-1974 – Student of the Moscow State University, Chemical Faculty, Department of Chemistry of Natural Compounds.

2005 – Professor, Diploma on Genetics and Biotechnology, Ivan Franko National University of Lviv;

2001 – DrSc. (habilitation) Thesis "Pathways of energy supply and detoxification in methylotrophic yeasts and their directed modification for development of enzymatic and biosensor analytical systems". Speciality: Biochemistry;

1983 – Associated Professor (Docent) Diploma on Biochemistry, Ivan Franko State University of Lviv;

1978 – Ph.D Thesis "Multiple molecular forms of equine pepsin", Moscow State University. Speciality: Bioorganic Chemistry, Chemistry of Natural and Biologically Active Compounds.

2012 (October-November) – Wroclaw University (Poland), visiting professor;

2000 (August–September) – Leeds and Oxford Universities (United Kingdom);

1996 (November-December) – Florence University (Italy), Chemical Department;

1995 (September-October) – Florence University (Italy), Chemical Department;

1991 (October-November) – Wroclaw University (Poland), Institute of Microbiology;

1985 (February-June) – Moscow State University, Biological Faculty, Department of Biochemistry.

2018 – Winner of the State Prize of Ukraine in Science and Technology;

1993 and 1998 – Awards of Soros International Science Foundation.

2008–2016 – University of Rzeszow (Poland), Department of Biotechnology, Professor;

2006–2007 – Ivan Franko Pedagogical University of Drohobych, Professor;

2002–2005 – Ibid, Department of Genetics and Biotechnology, Professor;

1987–1997 – Ibid, Department of Genetics and Biotechnology, Associated Professor (Docent);

1980–1985 – Ivan Franko State University of Lviv, Department of Biochemistry, Associated Professor (Docent).

1. Mechanisms of degradation of peroxisomal and cytosolic proteins in yeasts.
2. Regulation of flavinogenesis in non-conventional yeasts.
3. Production of biofuel ethanol by fermentation of lignocellulosic hydrolysates by yeasts.
4. Biotechnological production of proteins important for medicine and diagnostics.

Author of more than 300 scientific publications, including 85 full-length papers and 15 inventions (more than 75 – in journals with impact factor). Hirsch index (h-index) of publications – 21 (Scopus).

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2018-present – Deputy Director for Science, Institute of Cell Biology, NAS of Ukraine.

2018-present – Head of Laboratory of Metabolic Engineering, Institute of Cell Biology, NAS of Ukraine.

1998-2018 – Engineer, Scientist and Leading Scientist, Institute of Cell Biology, NAS of Ukraine.

1995-1999 – Student of Ivan Franko National University of Lviv, Faculty of Biology, Department of Genetics and Biotechnology.

2024 – Corresponding Member of NAS of Ukraine.

2016 – Doctor of Biological Sciences (Dr.Sc.), Microbiology.

2011 – Senior Scientist.

2006 – Candidate of Biological Sciences (Ph.D), Microbiology.

10.2019-11.2019 – Department of Biotechnology, University of Natural Resources and Life Sciences (Vienna, Austria).

01.2017-03.2017 – Department of Biology and Biological Engineering, Chalmers University of Technology (Gothenburg, Sweden).

10.2013-12.2013 – Department of Microbiology and Immunology, University of Texas, San Antonio Health Science Center (San Antonio, Texas, USA).

10.2012-12.2012 – Institute of Microbiology and Biochemical Technology, United States Department of Agriculture, USDA (Madison, Wisconsin, USA).

10.2007-03.2008; 10.2008-12.2008 – Ruhr-University, Faculty of Chemistry and Biochemistry, Electroanalysis and Sensors (Bochum, Germany).

10.2004-09.2005 – University of Cologne, Institute of Biochemistry (Cologne, Germany).

10.2002-12.2002 – Danish Technological University (Copenhagen, Denmark).

07.1999-10.1999 – Institute of Molecular Biology and Genetics of NAS of Ukraine, Department of Cell Regulatory Mechanisms (Kiev, Ukraine).

2021-2023 – Honorary ambassador of Lviv.

2009, 2011, 2020 – Laureate of premium of the Lviv regional state administration.

2019 – National Academy of Sciences of Ukraine award for professional achievements.

2019 – Recipient of a scholarship from the Lviv System of Researchers program by the Lviv City Council.

2011 – Laureate of the State Prize of Ukraine in the field of science and technology.

2009 – President of Ukraine award laureate.

Member of the Ukrainian Biochemical Society.

Member of the Society of Microbiologists of Ukraine named after S.M. Vinohradskyi.

Member of the Shevchenko Scientific Society.